The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity
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چکیده
منابع مشابه
The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity
During postnatal development, closure of critical periods coincides with the appearance of extracellular matrix structures, called perineuronal nets (PNN), around various neuronal populations throughout the brain. The absence or presence of PNN strongly correlates with neuronal plasticity. It is not clear how PNN regulate plasticity. The repulsive axon guidance proteins Semaphorin (Sema) 3A and...
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Introduction: Semaphorin 3A (Sema 3A) is a secreted protein, which plays an integral part in developing the nervous system. It has collapse activity on the growth cone of dorsal root ganglia. After the development of the nervous system, Sema 3A expression decreases. Neuropilin 1 is a membrane receptor of Sema 3A. When semaphorin binds to neuropilin 1, the recruitment of oligodendrocyte precurso...
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Chondroitin sulfate (CS) and the CS-rich extracellular matrix structures called perineuronal nets (PNNs) restrict plasticity and regeneration in the CNS. Plasticity is enhanced by chondroitinase ABC treatment that removes CS from its core protein in the chondroitin sulfate proteoglycans or by preventing the formation of PNNs, suggesting that chondroitin sulfate proteoglycans in the PNNs control...
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The amyloid precursor protein (APP) is well known for giving rise to the amyloid-β peptide and for its role in Alzheimer's disease. Much less is known, however, on the physiological roles of APP in the development and plasticity of the central nervous system. We have used phage display of a peptide library to identify high-affinity ligands of purified recombinant human sAPPα(695) (the soluble, ...
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1Department of Neuroscience, Neuroscience Institute of Turin (NIT), University of Turin, 10100 Turin, Italy 2Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (NICO), Regione Gonzole 10, Orbassano, 10043 Turin, Italy 3Netherlands Institute for Neuroscience (NIN), 1105 BA Amsterdam, Netherlands 4John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University o...
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ژورنال
عنوان ژورنال: Neural Plasticity
سال: 2016
ISSN: 2090-5904,1687-5443
DOI: 10.1155/2016/3679545